Salivary diagnosis of oral cancers by salivary samples: a systematic literature review

The aim of this article is to carry out a systematic analysis the literature concerning diagnosis oral cancers by salivary samples. Different biomarkers, produced tumor itself or its environment, show significant variations in their concentration at level, correlated not blood tissue level. After studying 239 articles, we included 36 analysis. This allowed us extract 46 potential molecules for diagnostics. Only 26 demonstrated good level evidence. 8 clusters have also been proposed better specificity and sensitivity. To date, protocols studies carried do allow affirm that one more biomarkers are effective cancers. Part results contradict sometimes lack precision. In addition, here methodological quality always take into account other factors influencing concentrations (systemic diseases, age, sex, tobacco, alcohol, etc .). Additional still necessary, notably with larger groups patients, representative general population standardization study quantification biomarkers.